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Trilostane is an adrenocortical suppressant used to treat Cushing’s disease in dogs You may buy Trilostane from CareFirst Specialty Pharmacy with a valid prescription from your prescriber.
Please Note: Due to market volatility, prices are subject to change. Please contact us for the most current pricing.
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To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.
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Fax (800) 786-1405 or (844) 922-7379 and we’ll process it right away.
Call our pharmacists at (844) 822-7379 with prescription details.
Complete the prescriber form and we’ll follow up quickly.
csr@cfspharmacy.com for questions, refills, or status updates.
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Trilostane is a 3-β hydroxysteroid dehydrogenase inhibitor that is used in the treatment of hyperadrenocorticism and Cushing’s disease in dogs and cats. By blocking this enzyme, trilostane stops the conversion of pregnenolone to progesterone, which decreases cortisol and aldosterone production. Lowering excessive cortisol production can help reduce symptoms associated with hyperadrenocorticism and improve quality of life. You may buy Trilostane from CareFirst Specialty Pharmacy with a valid prescription from your prescriber.
Trilostane
Consult your prescriber.
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.
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Learn more about Trilostane Tablets Compounded from our pharmacy team.

This medication works as a steroidogenesis inhibitor, reducing cortisol production by blocking the enzyme 3β-hydroxysteroid dehydrogenase, which is necessary for cortisol synthesis.

Trilostane is the only FDA approved medication for treating Cushing’s disease in dogs. It is a steroidogenesis inhibitor, which means it works to block the production of glucocorticoids and mineralocorticoids. This is helpful for patients with Cushing’s disease, who suffer from excess amounts of cortisol being synthesized by the body.

Like humans, pets can suffer from hormonal changes and disorders as they age. These can cause them to act strangely and change in appearance. One of the most common of these disorders is Cushing's disease. While rare in humans (1-2 cases/million people per year), Cushing's is quite common in pets, particularly in dogs, occurring in 1-2 out of every 1000 dogs per year.

Cushing’s Disease and Compounded Trilostane Dogs can suffer from endocrine (hormonal) diseases much like people. Cushing’s disease (hyperadrenocorticism or HAC) is an endocrine disorder, in which dogs produce too much cortisol hormone. 80% of dogs with Cushing’s disease have the pituitary-dependent form, while the remaining are affected by an adrenal gland tumor. Cushing’s disease affects the multiple functions throughout the dog’s entire body.